Compare fixed-policy disease decisions between two ClinVar releases

Returns the disease-level policy relation for two imported releases under one configured ClinVarbitration profile. The profile and pinned policy version are held fixed; this function does not calculate case rankings or evaluation summaries. transition_status is "inserted", "withdrawn", "changed", or "unchanged". classification_changed is true only for a retained allele-and-disease key whose policy classification changed. A changed status also covers changed gold-star evidence level or retained evaluation date.

Usage

rclinvarbitration_disease_release_transitions(
  con,
  old_release_id,
  new_release_id,
  profile_id = "default"
)

Arguments

con

A DuckDB DBI connection initialized with rclinvarbitration_init().

old_release_id

Earlier imported ClinVar release label.

new_release_id

Later imported ClinVar release label.

profile_id

Configured policy profile identifier, normally "default".

Value

A data frame at the allele-and-disease decision grain, suitable for filtering temporal reclassification cases.