ClinVarbitration policy SQL

Returns DuckDB views implementing the supported policy over clinvar_disease_submissions. The policy bins submitted classifications, excludes unknown bins and applies the upstream policy's intended qualified Illumina benign exclusion, optionally applies profile-specific submitter exclusions, prefers evidence evaluated from 2016 onward while always retaining expert-panel and practice guideline evidence, and applies the 60/20 majority rule. The disease-level and allele-level views both reproduce the upstream strong-review rule: the first retained practice-guideline or expert-panel classification in source order is decisive.

Usage

rclinvarbitration_policy_sql(
  policy_version = rclinvarbitration_policy_version()
)

Arguments

policy_version

Exact supported policy version. See rclinvarbitration_policy_version().

Value

A named character vector of DuckDB CREATE OR REPLACE VIEW statements.

Details

clinvar_policy_pathogenic_alleles is the disease-specific pathogenic or likely-pathogenic join surface for downstream Rduckhts/DuckHTS annotation. It does not perform VEP or PM5 computation.